Frontier Pharma-Schizophrenia-Diverse First-in-Class Pipeline Shows Promise for Treatment of Negative and Cognitive Symptoms

Schizophrenia is a chronic mental disorder that affects 1% of the population-equivalent to 51 million people worldwide-and is ranked among the top 10 causes of disability in developed countries. It is a debilitating condition that affects those afflicted, their families and society as a whole.

In 2013, the direct and indirect cost of schizophrenia to US society was estimated to be $155 billion. Despite this, the schizophrenia pipeline is relatively small. This is indicative of a low level of R&D funding and investment in schizophrenia, most likely due to a poor understanding of the underlying mechanisms of the disease, which hinders the development of effective pharmaceutical drugs.

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There are marketed pharmaceutical products that are effective in treating the positive symptoms of schizophrenia, but none are available for the treatment of negative and cognitive symptoms. There is no single pharmacological drug that addresses all the symptoms of schizophrenia, and therefore it is likely that in the future combined treatments based on pharmacogenetics will be used to provide a tailored approach.

As such there is a strong rationale for continued R&D investment in schizophrenia therapeutics, due to the high levels of unmet need across a large population. This report assesses first-in-class innovation across the schizophrenia pipeline.

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Table of Contents:

1 Table of Contents 2

2 Executive Summary 5

3 The Case for Innovation 6

4 Clinical and Commercial Landscape 10

5 Assessment of Pipeline Product Innovation 20

6 Schizophrenia Pathophysiology and Innovation Alignment 30

7 First-in-Class Molecular Target Evaluation 33

8 Deals and Strategic Consolidations 47

9 Appendix 57

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Posted by on Monday May 20 2019, 5:45 AM EDT. All trademarks acknowledged. Filed under Business & Financial Services, Business Services, Featured Press Release, Healthcare, Life Sciences, Pharmaceuticals. Comments and Trackbacks closed. Follow responses: RSS 2.0

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